Neutrophil-derived resistin release induced by Aggregatibacter actinomycetemcomitans
نویسندگان
چکیده
منابع مشابه
Neutrophil-derived resistin release induced by Aggregatibacter actinomycetemcomitans.
Resistin is an adipokine that induces insulin resistance in mice. In humans, resistin is not produced in adipocytes, but in various leukocytes instead, and it acts as a proinflammatory molecule. The present investigation demonstrated high levels of resistin in culture supernatants of neutrophils that are stimulated by a highly leukotoxic strain of Aggregatibacter actinomycetemcomitans. In contr...
متن کاملModulation of neutrophil chemotaxis by Aggregatibacter actinomycetemcomitans leukotoxin
Objective: Aggressive periodontitis (AgP) is frequently associated with the presence of Aggregatibacter actinomycetemcomitans, a Gram-negative pathogen, which expresses leukotoxin (Ltx) as a virulence factor. Ltx is known to disturb neutrophil function and to activate these cells. This study was aimed at investigating the ability of Ltx to alter the chemotactic behaviour of neutrophils, the mos...
متن کاملProteomics of Protein Secretion by Aggregatibacter actinomycetemcomitans
The extracellular proteome (secretome) of periodontitis-associated bacteria may constitute a major link between periodontitis and systemic diseases. To obtain an overview of the virulence potential of Aggregatibacter actinomycetemcomitans, an oral and systemic human pathogen implicated in aggressive periodontitis, we used a combined LC-MS/MS and bioinformatics approach to characterize the secre...
متن کاملIrsogladine maleate regulates neutrophil migration and E-cadherin expression in gingival epithelium stimulated by Aggregatibacter actinomycetemcomitans.
Irsogladine maleate (IM) counters Aggregatibacter actinomycetemcomitans-induced reduction of the gap junction intercellular communication and the expression of zonula occludens-1, which is a major tight junction structured protein, in cultured human gingival epithelial cells (HGEC). In addition, IM obviates the A. actinomycetemcomitans-induced increase in interleukin (IL)-8 levels in HGEC. Thus...
متن کاملAggregatibacter actinomycetemcomitans – Induced Release of NETs from Human Neutrophils under Anaerobic Conditions
The periopathogen Aggregatibacter actinomycetemcomitans is associated with aggressive periodontitis, a severe disease that causes rapid tooth loss among young adolescents. A. actinomycetemcomitans produce and secrete leukotoxin a pore forming protein which causes death of human polymorphonuclear leukocytes (PMNs) such as neutrophils. PMNs are the most abundant leukocyte and have important defen...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: FEMS Microbiology Letters
سال: 2011
ISSN: 0378-1097
DOI: 10.1111/j.1574-6968.2011.02334.x